United issued a statement regarding Wayne Rooney's injury on Saturday evening.
The brief statement read as follows: "Wayne Rooney has a fracture of the base of the fourth metatarsal on his right foot.
"He will be out for six weeks."
Rooney was stretchered off the field in the 82nd minute of United's 3-0 defeat by Chelsea at Stamford Bridge. He will now miss the club's last two matches against Middlesbrough on Monday night and against Charlton next Sunday.
England's opening World Cup match is on 10 June against Paraguay.
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The brief statement read as follows: "Wayne Rooney has a fracture of the base of the fourth metatarsal on his right foot.